NEW ORLEANS -- Drew Brees has set an NFL record with touchdown passes in 48 straight games, breaking the mark set by Johnny Unitas a half-century ago.
The record-setting scoring strike was a 40-yard pass to Devery Henderson against the San Diego Chargers on Sunday night.
Unitas set the record between 1956 and 1960 and no one had come within 10 games until Brees began to close in late last season. Tom Brady has the third-longest streak, extending his to 37 games Sunday in a victory over Denver.
Buffalo Bills crushed by Sand Fransico 49ers
SAN FRANCISCO -- Alex Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and the San Francisco 49ers amassed a franchise-record 621 yards in blowing by the Buffalo Bills 45-3 on Sunday.
Michael Crabtree and Vernon Davis each eclipsed 100 yards receiving to back Smith, who threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career.
Rian Lindell kicked a 31-yard field goal in the first quarter before San Francisco scored the final 42 points handing the Bills another embarrassing loss.
Robert Griffin III leaves game with mild concussion
LANDOVER, Md. -- Michael Turner ran 13 yards for the go-ahead score with 2:46 to play, and Atlanta knocked Robert Griffin III out of the game, en route to a 24-17 win.
The Falcons are 5-0 for the first time
Matt Ryan completed 34 of 52 passes for 345 yards as Atlanta handed Washington its eighth consecutive home loss.
Griffin left the game in the third quarter after being hit in the head on a sack by linebacker Sean Weatherspoon. Coach Mike Shanahan said RG3 has a "mild concussion."
Steelers edge Eagles
PITTSBURGH -- Shaun Suisham hit a 34-yard field goal as time expired to edge the Steelers over the Eagles 16-14.